According to a BBC press release former "ER" actress Alex Kingston and James Bond film regular Colin Salmon are among those featured in the upcoming season.
Here's the skinny:
British actors Alex Kingston and Colin Salmon have joined the stellar line-up of guest stars for the fourth series of BBC One's BAFTA award-winning drama Doctor Who.
Alex Kingston, best known for roles in ER and Moll Flanders, will appear in a Steven Moffat penned two-parter as River Song – a mysterious character who meets The Doctor on an expedition to uncover the secrets of an abandoned library.
She is joined by James Bond regular, Colin Salmon who also stars in the two episodes.
Alex Kingston comments: "I used to watch Doctor Who through the crack in the door. I was so terrified but I couldn't tear myself away. I loved it so much and I'm so delighted to be a part of the new series."
Award-winning actress Catherine Tate is reprising her role as Donna, the runaway bride, and will star as The Doctor's companion throughout the new series alongside David Tennant as The Doctor.
The first episode of the eagerly awaited new series will witness Donna tracking down The Doctor during an alien emergency in modern-day London.
The couple are destined to experience a series of wonderful adventures throughout the series including meeting one of Doctor Who's most popular aliens, The Ood, in a brand new episode, Planet Of The Ood.
Donna and The Doctor will also be travelling through time for an encounter with the legendary murder mystery novelist Agatha Christie and taking a trip to Pompeii.
Further guest stars already confirmed to appear in the new series include Sarah Lancashire, Felicity Kendal, Lesley Sharp, Georgia Moffett, Lindsey Coulson, Fenella Woolgar, Tim McInnerny, Peter Capaldi, Phil Davis and Tracey Childs.
Freema Agyeman who has played Martha Jones, The Doctor's companion throughout the critically-acclaimed third series, will also return to the show to join The Doctor and Donna mid-series.
The fourth series of Doctor Who is now in production and will hit BBC One in Spring 2008.
Wish her all the best miss Alex Kingston she is very smart how so sweet girl.
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